英國有位婦人(Diane)在2001年發生嚴重著車禍,造成小腿骨(Tibia)和大腿骨(Fibula)粉碎,在歷經十一次的手術後,必須面臨截肢的命運..
在看過Sky News對骨科權威醫師Anan Shetty利用"幹細胞治療登山者的腿部"之報導後,Diane決定尋求幹細胞的治療.
Dr.Anan Shetty抽取Diana骨髓幹細胞,將其與膠體物質Surgifill混合,置入骨頭受損位置,幹細胞會開始附著生長,直到完全癒合為止.藉由健康的骨頭加上打入幹細胞與支架組織(orthopaedic scaffold)還可增長骨頭的長度.
Diana藉由Sky News表示很高興能接受幹細胞的移植,並相信粉碎的骨頭組織能全部重新建立.Anan Shetty醫師評估再過18個月骨組織就可以完全恢復,癒合完成.
Anan Shetty a leading orthopaedic surgeon checks Diane Stuttard's leg after the operation Photo: SKY NEWS
Stem cells used to save woman's leg
Diane Stuttard had her lower left leg broken after being hit by a car while she walked home after a night out in 2001.
Both the tibia and fibula were shattered and she faced having the leg amputated after 11 operations.
However, she then contacted Anan Shetty, a leading orthopaedic surgeon, after seeing a Sky News report about him using stem cells to save the leg of a climber.
During her operation, at the private Spire Alexandra Hospital in Chatham, Kent, stem cells from her bone marrow were taken and mixed with a gel called Surgifill, which trapped the cells against the fracture. Within days they started to form healthy new bone, healing the break.
Surgeons also lengthened her leg by cutting into a healthy section of bone, injecting the stem cell mix and using an orthopaedic scaffold to gently pull the bone apart at a rate of almost half an inch (1cm) a month.
Although it is not the first time stem cells have been used in bone reconstruction, it is the first time the combination of stem cells, Surgifill and the leg lengthening technique has been used anywhere in the world.
She told Sky News: "I was advised to have the leg amputated by the surgeon in Leeds, but thankfully I said I wanted to wait until I had exhausted all avenues. I'm glad I did because this stem cell technique has come up and now it's my chance to get it right."
Mr Shetty said: "I am confident the fracture will join up. We managed to cut out all the dead bone and get into bleeding bone, which means that it is healthy. We also managed to use stem cells that will stimulate the bone to grow quicker."
The doctors and patient will have to wait 18 months before they can be sure the leg has healed properly.