韓國科學家日前發現,人類臍帶血幹細胞可以分化成內皮前驅細胞(endothelial progenitor cells; EPC),將內皮細胞移植到患有糖尿病的老鼠身上,可以加速傷口的癒合
糖尿病病患一旦有傷口通常難以癒合,這是因為病患的血糖過高,導致周邊血流量減少,血中帶有較少的生長因子(growth factor)和細胞激素(cytokine),因此血管新生速度較慢,傷口難以癒合
臍帶血幹細胞分化的內皮前驅細胞,可以促進血管新生,因此可以幫助傷口的癒合,這項發現已在動物實驗中被證實,並發表在細胞移植期刊中(Cell Transplantation)
Human umbilical cord blood cells accelerate diabetic wound healing
Korean scientists have found that transplanting human umbilical cord blood-derived endothelial progenitor cells (EPCs) 'significantly accelerate' wound closure in diabetic mouse models.
Diabetes is often associated with impaired wound healing, according to study's corresponding author, Wonhee Suh of the CHA University Stem Cell Institute.
"EPCs are involved in revascularization of injured tissue and tissue repair," said Suh.
"Wounds associated with diabetes that resist healing are also associated with decreased peripheral blood flow and often resist current therapies.
"Normal wounds, without underlying pathological defects heal readily, but the healing deficiency of diabetic wounds can be attributed to a number of factors, including decreased production of growth factors and reduced revascularization," he said.
For the study, the researchers transplanted EPCs into an experimental group of mice modeled with diabetes-associated wounds, but did not transplant EPCs into a control group.
They found that the EPCs "prompted wound healing and increased neovascularization" in the experimental group.
"The transplantation of EPCs derived from human umbilical blood cells accelerated wound closure in diabetic mice from the earliest point," said Suh.
The researchers found that growth factors and cytokines (small proteins secreted by specific cells of the immune system) were "massively produced" at the wounded skin sites and contributed to the healing process.
The study has been published in the current issue of Cell Transplantation. (ANI)
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