美國聖地牙哥的沙克生物研究中心目前發現，從人類鼻腔的嗅覺接收區分離間葉幹細胞(olfactory ectomesenchymal stem cells, OE-MSC)，再植入小鼠受損的大腦海馬迴區域，OE-MSC會自行跑到受損位置，分化成神經細胞，並促進神經細胞再生，因此可以恢復記憶力與學習力。這項研究已於6月13日發表在臨床研究期刊[Journal of Clinical Investigation]
Stem cells from smell-sensing region of human nose could treat brain disorders
A study on mice suggests that adult stem cells from immune system tissue in the smell-sensing region of the human nose could provide a source of cells to treat brain disorders in which nerve cells are lost or irreparably damaged.
A team of researchers led by Emmaluel Nivet, at the Salk Institute for Biological Studies, La Jolla, found that when human olfactory ectomesenchymal stem cells (OE-MSCs) were transplanted into mice with damage to the hippocampal region of the brain (a region important for memory and learning) they migrated toward the site of damage, where they developed into nerve cells and also stimulated endogenous nerve cell generation.
The treated mice showed improvements in learning and memory. This suggests that OE-MSCs might be of tremendous utility in the clinic.
SOURCE: Journal of Clinical Investigation, published online June 13, 2011
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