close
美國德克薩斯大學休士頓醫學中心日前發表以自體臍帶血治療新生兒聽力損傷,已進入第一期的人體臨床試驗。該試驗的主持人Dr. James Baumgartner表示,為期一年的試驗將招募十位病童,年齡為出生後6周到18個月,因基因異常或併發症所引起的後天性聽力損傷,經血液、聽力、語言的檢測,以及核磁共振檢視內耳到大腦的神經傳輸,確認為聽力異常者。 
 
治療方式為以靜脈注射病患自體臍帶血幹細胞(CBR提供),第一階段目標為評估臍帶血移植的安全性,第二階段目標為功能性檢測,分別於一個月及一年後做血液、聽力、語言的檢測,並在半年後加做核磁共振的細部檢測。 
 
Dr. James Baumgartner表示,新生兒只有18個月的時間培養語言學習能力,如有聽力損傷的問題,則會喪失語言學習的機會,導致無法正常講話。在美國,1000個18歲以下的孩童,就有6個有聽力損傷,其中9%為後天性因素導致的聽力損傷。希望臍帶血移殖能開啟非手術性的治療,幫助兒童恢復聽力,擁有語言學習的能力。
 
hearing_loss_infographic 
The Picture is form Cord Blood Registry (CBR).  
 
Cord blood stem cells may restore hearing
 
HOUSTON, Jan. 20 (UPI) -- U.S. researchers are undergoing a phase I safety study using a child's umbilical cord blood stem cells to try to restore hearing loss.

Dr. James Baumgartner, sponsor of the study and guest research collaborator at The University of Texas Health Science Center at Houston Medical School, said the yearlong study will follow 10 children, ages 6 weeks to 18 months, who have sustained post-birth hearing loss. Children who are deaf as a result of a genetic anomaly or syndrome are not eligible for the test.

"Children only have 18 months to acquire language skills and, if a child does not hear well, they will not acquire the language skills to speak normally," Baumgartner said in a statement.

The children will undergo a series of blood tests, hearing and speech tests and magnetic resonance imaging that will view the tracts that send signals from the inner ear to the brain.

Researchers will obtain and process the patients' stored cord blood for treatment and the stem cells will be given to the patients via IV infusion and patients will be observed for several hours in the hospital.

Patients will return to the hospital to repeat all tests except the MRI at one month and one year, and all tests

with an MRI at six months.

"This study is exciting because it might offer a non-surgical option for some children with profound hearing loss," Baumgartner said. "More importantly, this is the first treatment with the potential to restore normal hearing."


Read more: http://www.clinicaltrials.gov/ct2/show/NCT01343394?term=baumgartner+and+hearing+loss&rank=1
arrow
arrow
    全站熱搜

    幹細胞達人 發表在 痞客邦 留言(0) 人氣()