幹細胞論壇

「股骨頭壞死」素有「不死癌症」之稱，其主要病理為股骨頭遭受破壞而引起的股骨頭骨質缺血，多稱為股骨頭缺血性壞死或股骨頭無菌性壞死。嚴重危害著患者的身心健康，在股骨頭壞死發病早期症狀不太明顯，一般情況下對患者影響不大，因此時常給患者造成錯覺，容易錯失治療時機，一旦病情沒有得到有效地控制，就會造成大部分股骨頭消失，從而導致患者終身喪失勞動能力，無法進行正常生活。¹

    根據在Mol Med Rep.發表的文獻指出，使用臍帶間葉幹細胞可治療股骨頭壞死。該篇文獻針對9名股骨頭壞死的病患，其分期介於Ⅱ‑Ⅲa的患者進行動脈注射臍帶間葉幹細胞治療，並追蹤3年。結果發現，治療12和24個月後，患者股骨頭壞死體積明顯減少，沒有其他不良反應。數據指出，通過動脈注射的臍帶間葉幹細胞，移動到股骨頭壞死區域，分化為「成骨細胞」，進而改善股骨頭壞死。研究顯示，使用臍帶間葉幹細胞治療股骨頭壞死，是可行且安全的方法。²

註：

股骨(femur)是人體最長的骨頭，又稱為大腿骨。它的最上端形成一個圓球，連成髖關節的一部份。髖關節是由髖臼及股骨頭所組成³，其組成如下圖所示⁴：

參考文獻：

1. https://kknews.cc/zh-tw/health/65k693.html

2. https://www.ncbi.nlm.nih.gov/pubmed/27634376

    Mol Med Rep. 2016 Nov;14(5):4209-4215.

3. https://www.ntuh.gov.tw/orth/education/DocLib/%E8%82%A1%E9%AA%A8%E9%A0%AD%E5%A3%9E%E6%AD%BB.aspx

4. https://pic.pimg.tw/prpp3562350/1467117372-3784992836_n.jpg?v=1467117380

Efficacy of umbilical cord-derived mesenchymal stem cell-based therapy for osteonecrosis of the femoral head: A three-year follow-up study.

Abstract

This is a retrospective analysis of the clinical effects of transplant of mesenchymal stem cells (MSCs) derived from human umbilical cord-derived MSCs (hUC‑MSCs) for the treatment of osteonecrosis of the femoral head (ONFH). The biological characteristics of hUC-MSCs were assessed using flow cytometry. Nine eligible patients were enrolled in the study as they adhered to the Association Research Circulation Osseous (ARCO) classification of stage Ⅱ‑Ⅲa, and hUC‑MSCs were grafted by intra‑arterial infusion. Organize effective perfusion was assessed using the oxygen delivery index (ODI). The results showed that the ODI was increased at three days post‑operation. The MRI results revealed that at 12 and 24 months after treatment, the necrotic volume of the femoral heads was significantly reduced. No obvious abnormalities were observed. Taken together, these data indicate that intra‑arterially infused hUC‑MSCs migrate into the necrotic field of femoral heads and differentiate into osteoblasts, thus improving the necrosis of femoral heads. This finding suggested that intra‑arterial infusion of hUC‑MSCs MSCs is a feasible and relatively safe method for the treatment of femoral head necrosis.

Mol Med Rep. 2016 Nov;14(5):4209-4215.